Squeezing dendritic necks

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Squeezing dendritic necks

Squeezing dendritic necks Sure enough, diffusion restriction was induced in individual dendrites by pairing two excitatory signals from pre-synaptic and postsynaptic sources. The clampdown at the dendrite neck may involve cross-linking of an actin mesh, or blockage by mitochondria or smooth endoplasmic reticulum. Either way, says Sabatini, “if a spine can hold onto [molecules such as] active ki...

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Excitatory glutamatergic synapses at dendritic spines exchange and modulate their receptor content via lateral membrane diffusion. Several studies have shown that the thin spine neck impedes the access of membrane and solute molecules to the spine head. However, it is unclear whether the spine neck geometry alone restricts access to dendritic spines or if a physical barrier to the diffusion of ...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2005

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb1715rr3